Unmet need
NMIBC
According to American Cancer Society (ACS) projections, in 2024, an estimated 83,000 Americans will be diagnosed with bladder cancer.5 Of them, more than 75% are diagnosed with high-risk non-muscle invasive bladder cancer (NMIBC) and receive initial treatment with intravesical immunotherapy Bacillus Calmette-Guérin (BCG).6 These patients will likely experience disease recurrence and progression within 1 year, and many will become unresponsive to BCG treatment.6
Advanced prostate cancer
In 2022, there were 230,125 new cases of prostate cancer leading to 33,746 deaths in the US.4 Cardiovascular disease (CVD) and cardiovascular (CV) risk factors increase with age, and CVD incidence and mortality are higher in men with prostate cancer compared to those without.7,8